Table 3.
Physical properties of formulated salbutamol matrix tablets using graft copolymers and HPMC K100M as release retardants. (All values are expressed as mean ± SD, n=3).
| Formulation code | Weight deviation (mg) | Hardness (Kg/cm 2 ) | Friability (%) | Thickness, mm | % Drug content |
|---|---|---|---|---|---|
| F1 | 204 ±2.1 | 3.27 ±0.57 | 0.75 ±0.24 | 3.24 ±0.22 | 102.47 ±2.6 |
| F2 | 206 ±2.1 | 3.35 ±0.87 | 0.53 ±0.21 | 3.26 ±0.52 | 100.98 ±2.3 |
| F3 | 203 ±1.9 | 3.49 ±0.92 | 0.69 ±0.17 | 3.37 ±0.47 | 101.57 ±2.8 |
| F4 | 205 ± 2.3 | 4.01 ± 0.53 | 0.77 ± 0.29 | 3.19 ± 0.38 | 104.21 ± 2.9 |
| F5 | 204 ± 2.7 | 3.76 ± 0.73 | 0.84 ± 0.19 | 3.41 ± 0.29 | 103.61 ± 3.1 |