Table 5.
Pharmacokinetic parameters of formulated (F1, F2, F3, F4 & F5) and marketed tablets (Asthalin SA) of salbutamol sulphate in rabbits (n=3).
| Pharmacokinetic parameters | F1 | F2 | F3 | F4 | F5 | Asthalin SA |
|---|---|---|---|---|---|---|
| Maximum plasma concentration, Cmax (ng/ml) | 924.1 ± 10.1 | 812.4 ± 7.9 | 578.9 ± 9.1 | 546.7 ± 8.9 | 598.1± 10.7 | 601.9 ± 6.3 |
| Time required to reach maximum plasma concentration, tmax (h) | 1.5 ± 0.23 | 2.5 ± 0.47 | 6.0 ± 1.3 | 7.5 ± 1.2 | 6.2 ± 1.1 | 7.1± 0.75 |
| Area under curve at 24h, AUC (ng-h/mL) | 5261.19 ± 5.1 | 4979.52 ± 5.1 | 6460.12 ± 8.3 | 6679.48 ± 7.5 | 6276.34 ± 6.8 | 6592.28 ± 6.8 |
| Elimination rate constant, Ke (h-1) | 0.127 ± 0.017 | 0.103 ± 0.019 | 0.057 ± 0.011 | 0.053 ± 0.011 | 0.049 ± 0.012 | 0.059 ± 0.014 |
| Plasma half life, t1/2 (h) | 5.45 ± 0.59 | 6.72 ± 0.31 | 12.15 ± 0.91 | 13.07 ± 1.21 | 14.14 ± 1.09 | 14.43 ± 0.87 |