Table 1.

A comparison with other references

			Ref 3	Ref 2	Ref 6		Present work
					Two step process	Single pot process
Chloromethylation Step	Mixing	AlCl3 (mol)	0.139 c	64.54	0.139 c	32.37	0.26
		HFIP (mol)	0.139 c	64.54	0.139 c	32.37	0.24
		1,3,5-Trioxane (mol)	0.047 c	21.58	0.046 c	10.79	0.08
		Reaction Time (h)	24	24	20 f	Did not mention	4
		HCl gas a	Evaluated	Absorbed d	Evaluated	Absorbed d	Reused i
		Monitoring the reaction	By GC	By GC	By GC	By GC	By 19F NMR
	Quenching	HCl 6N (L)	0.050	26.6	0.050 g	13.3	0.040
		Water (L)	Did not mention clearly	10	0.050	5	0.040
		Aqueous Phase b	Did not mention	Siphoned off	Did not mention	Siphoned off	Analyzed by 19F NMR j
		Quenching Time	Did not mention	Did not mention	Did not mention clearly	Did not mention	50 minuets k
Fluorination Step	SVC (mol)		0.010	Did not mention e	0.010	Did not mention e	0.18
	KF (mol)		0.040	Did not mention	0.040	97.26	0.22
	PEG-400 (L)		0.010	32	------ h	16	0.050

^aProduced during the reaction.

^bProduced by washing the mixture.

^c The number is rounded. ^dBy scrubbers containing water.

^eThe SVC didn’t separate because this reaction has been described as a one-vessel process.

^fThe reaction didn’t completed at this time because the mixture still had a little (<5% quantitatively) amount of bis-HFIP-acetal.

^gCold (-20 °C.).

^hdiethylene glycol was used as a solvent (0.010 L).

ⁱThe HCl gas was directed to a water bath and, after pH adjustment, was used for quenching the chloromethylation step.

^jThe aqueous phase contains some SVC that was extracted by a solvent.

^kThe quenching time depends on the reaction scale.