Table 2.

Influence of amount of solvent and KF on the fluorination of Sevochlorane

Entry a	PEG-400/mL	KF/mol L -1	Time/h	Sevoflurane yield (%) b	Unreacted Sevochlorane (%) b
1	20	0.07	2.5	96.4	3.6
2	20	0.04	2.5	95.5	4.5
3	20	0.02	2.5	94.5	5.5
4	5	0.02	2.5	93.6	6.4
5	2.5	0.02	2.5	90.3	9.7
6	0.5	0.02	2.5	41.8	58.2
7	0.5	0.02	5	51.1	48.9

^a All reactions were carried out on a 0.016 mol reaction scale of Sevochlorane in PEG-400 at 95 °C.

^{b 19}F NMR assay.