Figure 2.

Effects of different concentrations of L-NAME infusion on escape latency (A), traveled distance (B), and swimming speed (C) during the testing trials. Hippocampus infusion of L-NAME (1, 2 μg/side, i.h) showed a significant decrease in escape latency compared to the control group. Treatment by L-NAME (2 μg/side, i.h) decreased traveled distance significantly comparing to the control group (Figures 2 A and B).There was no significant difference in swimming speed between the control and the treatment groups (Figure 2C). Intra-hippocampal infusion of Aβ significantly increased the time and distance for finding the hidden platform comparing with the control group. Intra-hippocampal infusion of 1, 2 (μg/side) of L-NAME with Aβ decreased the time and distance for finding the hidden platform significantly in comparison with Aβ treated animals. Each point explains Mean ± S.E.M for 6-8 rats. (*P < 0.05; ***P < 0.001 different from control group, #P < 0.05; ##P < 0.01; ###P < 0.001 different from Aβ-treated group