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. 2015 Summer;14(3):811–824.

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© 2015 by School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Interactive effect of administration of bilateral intra-hippocampal infusion of Aβ and different doses of L-NAME on time spent in target quadrant in 90 sec probe test. Treatment with L-NAME (2 μg/side, i.h) significantly increased the time animals spent in the target quadrant comparing to control. Furthermore administration of Aβ (30 ng/side) into the CA1 region of the hippocampus decreased this time significantly compared to the control. The time increased significantly by administration of 1or 2 (μg/side) of L-NAME after infusion of amyloid beta comparing to Aβ-treatment group. Each point shows the mean ± SEM for 6–8 rats. (*P < 0.05; **P < 0.01 different from control group, #P < 0.05 different from Aβ-treatment group).