Figure 1.

Classification of macular drusen. Every elevation of the retinal pigment epithelium detectable in the single B-scans (Top left image) was delineated. In a next step, drusen were classified using 3 internal druse characteristics based on the spectral-domain optical coherence tomography classification (shape, reflectivity, and homogeneity, center and right area) and for specific depolarizing characteristics (foci and content, right and bottom area—the red color in the B-scans represents depolarizing structures segmented based on the degree of polarization uniformity calculation). Note that foci could be hyperreflective and/or depolarizing (foci, blue vs yellow arrow, respectively). Finally, the central slice of each single druse was selected (Bottom left images) and its position on the retina was noted for further statistical calculations.