. 2015 May 6;61(4):517–526. doi: 10.1093/cid/civ363

Table 3.

Effect of Doxycycline Treatment on Presence of Wolbachia in Worms

Treatment Group	Time, mo	No. of Patients/ Nodules^a	No. of Living Female Worms^b				No. of Living Male Worms^b
			All^c	With Wolbachia^d			All^c	With Wolbachia^d
			All^c	Many	Few	None	All^c	Many	Few	None
Doxycycline (6 wk)	20	56/152	117	1	5	111	41	0	3	36
Placebo	20	63/199	184	60	80	35	54	5	19	26

^a Only evaluable patients/nodules are included; nodules with newly acquired worms only are subtracted.

^b Newly acquired worms were subtracted (doxycycline, n = 8 females; placebo, n = 7 females).

^c Although the number of all living worms is given to make the numbers consistent to the other tables, in 15 worms, it was not possible to distinguish if the worm had many, few, or no Wolbachia, due to too little worm material in the respective histological sections. Therefore, “All” is not always a summary of the 3 categories.

^d Significant difference between the doxycycline and the placebo group regarding absence of Wolbachia (^bP < .001 for female and male worms respectively, Fisher exact test).