Table 3.
Arterial stiffness changes by drug assignmenta,b.
| Simvastatin | Placebo | |||
|---|---|---|---|---|
| Baseline | Study end | Baseline | Study end | |
| Peripheral PWV, m/s | 10.3 ± 1.9 | 10.4 ± 1.8 | 10.7 ± 2.5 | 10.2 ± 1.7 |
| Central SBP, mmHg | 115.1 ± 14.6 | 112.7 ± 11.6 | 113.3 ± 12.2 | 112.1 ± 13.3 |
| Central DBP, mmHg | 75.7 ± 6.9 | 75.1 ± 7.6 | 74.9 ± 6.9 | 74.5 ± 8.9 |
| AP, mmHg | 11.9 ± 6.4 | 11.4 ± 5.0 | 12.1 ± 5.2 | 10.9 ± 5.2 |
| AIx, % | 23.4 ± 9.4 | 23.5 ± 8.9 | 24.9 ± 9.4 | 23.0 ± 8.9 |
aData are means ± SD (n = 96). bAIx, augmentation index; AP, augmentation pressure; DBP, diastolic blood pressure; SBP, systolic blood pressure; PWV, pulse wave velocity. There were no differences at baseline (P ≥ 0.07) between nonmyalgic and myalgic participants within a treatment group.