Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jul 29;9:293. doi: 10.3389/fncel.2015.00293

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Greferath, Anderson, Jobling, Vessey, Martinez, de Iongh, Kalloniatis and Fletcher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Fos-Tau-LacZ (FTL) reporter expression increases in the rd1-FTL retina as a function of age. Flatmount retinae from control FTL (A, P135), rd1-FTL (B, P105; C, P135; D, P240; E, dark adapted rd1-FTL aged P210) mice were processed for FTL expression using β-galactosidase histochemistry. In contrast to the wild-type retina that showed FTL labeling throughout the retina (A), the rd1-FTL aged P105 (B) showed no FTL labeling. However, at P135 (C) rd1-FTL retina showed distinct labeling near the optic nerve, that subsequently expanded across the central retina (D,E). The expression of the FTL reporter as a function of retinal area was quantified at different ages from P105 to P365 (F). Data presented as mean ± SEM, n ≥ 8 per group, ^∗∗∗∗p < 0.0001 (one-way ANOVA). Scale bar for (A–E) = 1 mm.