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. 2015 Jul 29;9:293. doi: 10.3389/fncel.2015.00293

FIGURE 3.

FIGURE 3

Fos-Tau-LacZ reporter expression in the rd1-FTL retina is not due to cell death nor correlated with remodeled inner retina. Total and inner nuclear layer thickness measures were measured from vertical retinal sections in areas exhibiting FTL expression, as well as neighboring areas showing no FTL expression (A). Additionally, vertical sections of rd1-FTL retina were labeled for FTL (anti-β-galactosidase, green) and DAPI (blue). Inner retinal layer and total retinal thickness’ were similar between FTL+ sand FTL- regions (A). Increased FTL reporter expression was observed in inner retinal regions where the structure remained intact (B), as well as in regions where there was evidence of anatomical remodeling (arrows, C). Furthermore, other regions that exhibited DAPI labeled nuclei which were mislocated within the IPL, were FTL negative (arrows, D). Data presented as mean ± SEM, n ≥ 6 per group, p > 0.05 (two-way ANOVA). Abbreviations: INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. Scale bar: 50 μm.