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. 2015 Jul 29;5:12593. doi: 10.1038/srep12593

Figure 1. Detection of sympathetic tone in serum and condylar subchondral bone of 4-week control (4C) and 4-week experimental (4E) rats.

Figure 1

A, B: Norepinephrine (NE) levels in serum (A) and condylar subchondral bone (B) over the three time-points (2, 4 and 8 weeks) examined. C: control rats; E: experimental rats. Levels of significance: *P < 0.05, **P < 0.01. C: Immunofluorescent staining and quantification of the tyrosine hydroxylase (TH) positive sympathetic nerve fibers in the condylar subchondral bone of 4-week control and experimental groups. The dash line indicates the interface between cartilage (C) and subchondral bone (B). Arrows indicate TH-positive sympathetic nerve fibers (red color). The blue color indicates cell nuclei stained by DAPI. D: Real-time PCR analysis of the mRNA expression of β-adrenergic receptors (β-ARs) in the condylar subchondral bone of 4-week control and experimental groups. E: Immunohistochemical staining and quantification of the β2-AR (Adrb2) positive cells in the condylar subchondral bone of 4-week control and experimental groups. Levels of significance for all charts: *P < 0.05, **P < 0.01.