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. 2015 Jul 29;5:12624. doi: 10.1038/srep12624

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Copyright © 2015, Macmillan Publishers Limited

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(a–c) CA1 neurons were biolistically transfected with CCNY-WT (a) CCNY shRNA (b) or co-transfected with CCNY shRNA and shRNA-resistant CCNY-WT construct (Rescue; c), and recorded in whole-cell patch-clamp mode. LTP is blocked in CCNY-WT transfected neurons (a; •, n = 6) compared to untransfected control neurons (a; ●, n = 7). LTP is enhanced in CCNY shRNA transfected neurons (b; •, n = 6) compared to untransfected control neurons (b; ●, n = 6). The CCNY shRNA-mediated LTP enhancement was rescued back to the level (c; ●, n = 6) of untransfected control neurons (c; ●, n = 6) by co-transfecting with shRNA-resistant CCNY-WT construct. Data represent means ± SEM. (d) CCNY scrambled shRNA-expressing CA1 neurons elicit LTP (•, n = 6) to a level similar to untransfected control neurons (•, n = 6). Data represent means ± SEM.