Table 3. The associations between SNPs reported in the European GWAS and serum AAT levels in the Japanese population.
| SNP | Chr | Position | Gene | Ref/var | Location | The European study |
The current study |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | VAF | Effect | P | N | VAF | Effect | P | ||||||
| rs2736887 | 14 | 94812980 | SERPINA2A/SERPINA6 | G/C | Intergenic | 1,392 | 0.185 | 7.1 | 2.5 × 10−13 | 3,294 | 0.576 | 0.34 | 0.44 |
| rs926144 | 14 | 94813402 | SERPINA2A/SERPINA6 | A/G | Intergenic | 1,392 | 0.186 | 7.1 | 2.7 × 10−13 | 3,294 | 0.549 | 0.29 | 0.51 |
| rs4905179 | 14 | 94795492 | SERPINA6 | A/G | Upstream | 1,392 | 0.180 | 6.8 | 1.2 × 10−12 | 3,294 | 0.476 | 0.35 | 0.42 |
| rs11621961 | 14 | 94769476 | SERPINA6 | C/T | Downstream | 1,392 | 0.355 | 5.2 | 1.4 × 10−11 | 3,294 | 0.310 | 0.37 | 0.44 |
| rs2896268 | 14 | 94865708 | SERPINA1 | A/C | Upstream | 5,569 | 0.495 | 1.3 | 4.1 × 10−5 | 3,294 | 0.502 | 1.61 | 2.4 × 10−4 |
Chr, chromosome; N, number of subjects; P, P value calculated by generalized linear regression model; ref/var: reference allele/variant allele; VAF, variant allele frequency.
Effects in European sutdy are converted to mg dl−1.