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The possible effects of soy isoflavone genistein and tea polyphenolic compound EGCG on the Wnt pathway in breast cancer stem cells. Genistein re-expresses sFRP2 that is a Wnt antagonist and EGCG promotes the expression of HBP1 transcription factor that blocks TCF mediated cyclin D1 expression in breast cancer cells. sFRP: secreted frizzled-related protein, EGCG: (−)-epigallocatechin-3-gallate, GSK: glycogen synthase kinase, APC: adenomatous polyposis coli, TCF: T-cell factor
