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. Author manuscript; available in PMC: 2015 Jul 29.
Published in final edited form as: J Nutr Biochem. 2012 Jul;23(7):691–698. doi: 10.1016/j.jnutbio.2012.03.002

Figure 4.

Figure 4

EGCG reduces the expression of Polycomb group protein Bmi-1 and thereby may antagonize its oncogenic activity in skin cancer stem cells. Bmi-1 is a member of Polycomb repressive complex 2 (PRC2) that alters the histone structure into a suppressive form (H3K27me3), which down-regulates the expression of tumor suppressor genes including p16 and p19. EGCG reduces the expression of oncoprotein Bmi-1 and thus prevents the self-renewal of skin cancer stem cells. Yellow circles indicate suppressed histones and green, re-activated histones. PRC: polycomb repressive complex, Bmi-1: B-cell-specific moloney murine leukemia virus integration site 1 (Bmi-1), EGCG: (−)-epigallocatechin-3-gallate.