Table 1.

Biological evaluation of anti-inflammatory activities

Compound	Suppression of LPS-induced IL6, IL1β, and TNFα mRNA levels in IEC6 cellsa	Suppression of LPS-induced IL6, IL1β, and TNFα induction in RAW cellsb	Protection of IL6, IL1β, and TNFα induction in micec
7	58.0% (p<0.01)	50% (p<0.01)	<64% (p<0.01)
8	44% (p<0.01)	50% (p<0.05)	<60% (p<0.01)
9	<20%	<20%	<20%
13	<20%	<20%	<20%
14	<20%	<20%	48%
15	30%	32%	<20%
16 (C34; ref. 13)	55% (p<0.01)	50% (p<0.01)	69% (p<0.01)
17	43% (p<0.01)	50% (p<0.01)	78% (p<0.01)
18	54% (p<0.05)	50% (p<0.01)	64% (p<0.01)

Treatment and dosages:

^aIEC6 cells (LPS 25 µg/mL, compounds 5 µg/mL, 30 min pretreatment).

^bRaw cells (LPS, 10 ng/mL, compounds 5 µg/mL, 30 min pretreatment).

^cMice (LPS 2.5 mg/kg, compounds 2.5 mg/kg, 30 min pre-pretreatment).