Direct Inhibition of Ras-Erk Signaling Extends Lifespan
(A) Ubiquitous adult-onset expression of ras[DN] increases lifespan (p = 1.26 × 10−7). See Table S2A.
(B) Ubiquitous adult onset of ras85D knockdown by RNAi increases lifespan (p = 2 × 10−3). See Table S2B.
(C) Ubiquitous adult-onset knockdown of rl expression by RNAi increases lifespan (p = 1.46 × 10−7). See Table S2C.
(D) Adult gut/fat body expression of ras[DN] extends lifespan (p = 3 × 10−3). See Table S2D.
(E) Adult gut/fat body knockdown of ras85D expression by RNAi extends lifespan (p = 4 × 10−4). See Table S2E.
(F) Adult gut/fat body knockdown of rl expression by RNAi extends lifespan (p = 10−5). See Table S2F.