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. 2015 Jul 2;162(1):72–83. doi: 10.1016/j.cell.2015.06.023

Figure S6.

Figure S6

Trametinib Extends the Lifespan of daGS > ras[CA] and daGS > pnt[P1] Flies in the Absence of Transgene Expression, Related to Figure 5

(A and B) In the absence of RU486 and hence transgene expression, trametinib treatment at 15.6 μM increased the survival of daGS > ras[CA] flies (increase in median lifespan of 9%, p = 2.07x10−8) and daGS > pnt[P1] flies (increase in median lifespan of 9%, p = 2.69x10−7). Untreated daGS > ras[CA]: n = 90 deaths/6 censors, median lifespan = 82 days; trametinib-treated daGS > ras[CA]: n = 95/1, median lifespan = 89 days; untreated daGS/ pnt[P1], n = 141/6, median lifespan = 79 days; trametinib-treated daGS> pnt[P1], n = 132/19, median lifespan = 86 days.