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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Nat Chem. 2015 Jun 29;7(8):653–660. doi: 10.1038/nchem.2285

Figure 2.

Figure 2

Figure 2

Substrate anchoring mechanism employed by P450 PikC. (a) Co-crystal structure of natural substrate, YC-17, and PikC (PDB ID 2CD8)33 depicting the anchoring salt bridge between E94 and the dimethylamino group of YC-17. (b) Evolution of the PikC substrate-engineering approach with the natural anchoring group, desosamine and dimethylamine containing synthetic anchoring groups.