Table 7.
The distributions of haplotype frequencies of SNPs −9C>T and 368A>G in H2B.W gene in azoospermia according to testicular biopsy and fertile men
| Haplotype | Fertile men | Azoospermia (n=46) | P valuea | OR (95% CI)a | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total(n=60) | Men with hypospermatogenesis(n=8) | CMA(n=17) | SCOS (n=21) | 1 | 2 | 3 | 1 | 2 | 3 | ||
| CA | 33.30%(n=20) | 62.50%(n=5) | 17.60%(n=3) | 38.10%(n=8) | 0.602 | 0.359 | 0.358 | Reference | Reference | Reference | |
| TA | 30%(n=18) | 25%(n=2) | 52.90%(n=9) | 14.30%(n=3) | 0.366 | 0.104 | 0.244 | 0.444(0.077-2.581) | 3.333(0.779-14.26) | 0.417(0.096-1.815) | |
| CG | 26.70%(n=16) | 12.50%(n=1) | 23.50%(n=4) | 42.90%(n=9) | 0.226 | 0.54 | 0.564 | 0.25(0.026-2.361) | 1.667(0.325-8.549) | 1.406(0.442-4.473) | |
| TG | 10%(n=6) | 0 | 5.90%(n=1) | 4.80%(n=1) | 0.999 | 0.933 | 0.45 | 0(0.000--) | 1.111(0.097-12.750) | 0.417(0.043-4.034) | |
SNP; Single nucleotide polymorphisms, CMA; Complete maturation arrest, SCOS; Sertoli cell only syndrome, OR; Odd ratio, CI; Confidence interval, a; Controls vs. 1; Men with hypo spermatogenesis, 2; CMA and 3; SCOS vs. CMA.