Figure 3.
A Cluster of Redundant BH3-Only Proteins Promote Death in Mitosis
(A) Gene expression changes following Myc RNAi; y axis shows the fold change and circle sizes reflect the number of transcripts detected. Horizontal lines represent mean ± 1 SD.
(B–E) Fate profiles of RKO cells exposed to 0.1 μM taxol following tet-induced overexpression of Bcl-xL (B); RNAi-mediated co-repression of Myc and Bcl-xL (C); RNAi-mediated co-repression of Bim, Bid, and Noxa (D); and tet-induced overexpression of Bim following Myc RNAi (E).