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Inhibition of ICAD Enhances Slippage
(A) Fate profiles of RKO cells exposed to 0.1 μM taxol following ICAD RNAi.
(B) Fate profiles of RKO cells in the absence of taxol following RNAi-mediated co-repression Bcl-xL/Mcl1 plus tet-induced overexpression of TRF2. In (B), 0 hr represents when imaging started.
(C) Mechanistic model, see text for details.
See also Figure S7.
