Fig. 2.

In OIR, GKT137831 reduced inflammatory mediators in the retina. GKT137831 (GKT). mRNA levels were determined in the whole retina by quantitative PCR. Protein levels in the whole retina were measured by ELISA. a, b VEGF mRNA and protein. c, d MCP-1 mRNA and protein. e, f ICAM-1 mRNA and protein. g VCAM-1 mRNA. h PECAM-1 mRNA. *P < 0.05, **P < 0.01, and ***P < 0.001 to room air control. #P < 0.05, ##P < 0.01, and ###P < 0.001 to OIR control. n = 9 to 10 rats per group. Values are mean ± SEM