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. 2015 Jul 30;12:113. doi: 10.1186/s12985-015-0338-9

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© Li et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Histopathological lesions in experimental conventional pigs. a No markable microscopic lesions in the lung of mock group pigs. b Slight lymphoplasmacytic and histiocytic bronchointerstitial pneumonia in the lung of a pig vaccinated with 2×10^4.0 TCID₅₀ dose attenuated PCV1-2b. c Mild lymphoplasmacytic and histiocytic bronchointerstitial pneumonia in the lung of a pig vaccinated with inactivated PCV1-2b. d Moderate lymphoplasmacytic and histiocytic bronchointerstitial pneumonia in the lung of a pig vaccinated with 2×10^3.5 TCID₅₀ dose attenuated PCV1-2b. e Conspicuous lymphoplasmacytic and histiocytic bronchointerstitial pneumonia in the lung of a pig vaccinated with commercial inactivated PCV2b vaccine X. f Severe lymphoplasmacytic and histiocytic bronchointerstitial pneumonia in the lung of a nonvaccinated challenged pig. g No remarkable microscopic lesions in the lymph nodes of a pig in the mock group. h Slight lymphoid depletion (LD) in lymph node follicles of a pig vaccinated with 2×10^4.0 TCID₅₀ dose attenuated PCV1-2b. i Mild LD in lymph nodes follicles of a pig vaccinated with inactivated PCV1-2b. j Moderate LD in lymph nodes follicles of a pig vaccinated with 2×10^3.5 TCID₅₀ dose attenuated PCV1-2b. k Conspicuous LD in lymph nodes follicles of a pig vaccinated with commercial inactivated PCV2b vaccine X. l Moderate histiocytic replacement (HR) in lymph node follicles of a nonvaccinated challenged pig. Bar = 20 μm (400×)