Table 3.
| |||||
|---|---|---|---|---|---|
| compd | X | IC50 (μM)
|
|||
| Hsp90α | Hsp90β | Grp94 | Trap-1 | ||
| 9g | S | >300 | >300 | 0.12 ± 0.04 | 145.4 ± 13.4 |
| 14a | S= O | 24.9 | ND | 5.4 | ND |
| 14b | O=S=O | >25 | ND | 4.7 | ND |
| 14c | O | >100 | ND | 0.5 | ND |
| 14d | CH2 | >100 | ND | 0.7 | ND |
| 14e | C=O | >100 | ND | 0.34 | 4.98 |
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