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. Author manuscript; available in PMC: 2016 May 14.
Published in final edited form as: J Med Chem. 2015 Apr 22;58(9):3922–3943. doi: 10.1021/acs.jmedchem.5b00197

Table 5.

graphic file with name nihms708707u6.jpg
compd X R1 IC50 (μM)
Hsp90α Hsp90β Grp94 Trap-1
18a N 2′,4′-di-Cl 20.3 ± 1.2 ND 0.41 ± 0.1 ND
18c N 3′,5′-di-Cl 27.3 ± 3.5 41.8 ± 1.3 0.22 ± 0.08 7.3 ± 0.5
18d C 2′,4′-di-Cl >50 ND 3.44 14.1
18e C 3′,5′-di-Cl >50 ND 1.08 7.2
18f C I 0.028 ND 0.101 ND
18g N N(CH3)2 0.100 ND 0.265 ND
5 N I 0.043 ± 0.006 0.042 ± 0.003 0.026 ± 0.004 0.205 ± 0.006
22 – – 33a 38a 190a 1586a
a

Values were obtained from ref 22.