Table 1. Maximum response to noradrenaline, in absence or presence of indomethacin or L-NAME, obtained in two rings, one with and the other without endothelium, of the same thoracic aorta from sedentary and trained rats, submitted or not to stress.
Inhibitor | Groups | |||||||
---|---|---|---|---|---|---|---|---|
Sedentary | Trained | Stressed | Trained/Stressed | |||||
+E | –E | +E | –E | +E | –E | +E | –E | |
Without | 3.94±0.15 (n=9) | 5.25 ± 0.30† (n=9) | 2.82 ± 0.11* (n=10) | 4.92 ± 0.47† (n=10) | 2.80 ± 0.10* (n=9) | 5.28 ± 0.31† (n=8) | 2.97 ± 0.21* (n=10) | 5.12 ± 0.59† (n=8) |
Indomethacin | 2.61 ± 0.13# (n=8) | 5.10 ± 0.50† (n=8) | 2.99 ± 0.29 (n=7) | 4.95 ± 0.26† (n=7) | 1.86 ± 0.18*# (n=8) | 4.99 ± 0.29† (n=8) | 2.80 ± 0.18 (n=8) | 4.91 ± 0.19† (n=8) |
L-NAME | 5.23 ± 0.26# (n=7) | 4.95 ± 0.29 (n=7) | 5.28 ± 0.30# (n=8) | 5.11 ± 0.19 (n=9) | 5.55 ± 0.38# (n=8) | 5.57 ± 0.35 (n=7) | 4.42 ± 0.41# (n=8) | 5.28 ± 0.54† (n=8) |
Maximum response in gram of tension; (+E): with endothelium; (-E): without endothelium; stress: immobilization for 2 h; physical training: 60-min swimming session/5 days/week during 8 weeks, with 5% body weight load attached to the chest. *P<0.05 relate to sedentary group. #P<0.05 presence of inhibitor vs absence of inhibitor. †P<0.05 rings without endothelium vs rings with endothelium; values are means ± SEM; (n) = number of animals; the data were compared by two-way ANOVA and complemented with the multiple comparisons Tukey's test.