Fig. 1.

FGF21 decreased foam cell formation of THP1 derived macrophages. a Representative images and (b) the average integrated optical density (IOD) of lipid droplets stained with oil red O from differentiated macrophages treated by 50 mg/L ox-LDL in the presence or absence of 20 nmol/L FGF21 for 24 h. c The intracellular total cholesterol (TC) content was measured under the same conditions as in a. d Foam cells were identified by FACS assay, representative images of FACS (left) and the percentages of apoptosis cells (right). Data are presented as the mean ± S.E. of at least four independent experiments. *, p < 0.05, **, p < 0.01