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Tumorigenicity of A549-shSFN in SCID mice
| shRNA | T (%) | D (%) | DM (%) | |
|---|---|---|---|---|
| Intrabronchial | shSFN#1 | 0/4 (0) | 0/4 (0) | 0/4 (0) |
| (n = 4) | shSFN#2 | 2/4 (50) | 0/4 (0) | 0/4 (0) |
| shLuc | 4/4 (100) | 1/4 (25) | 0/4 (0) | |
| Intravenous | shSFN#1 | 0/4 (0) | 0/4 (0) | 0/4 (0) |
| (n = 4) | shSFN#2 | 0/4 (0) | 0/4 (0) | 0/4 (0) |
| shLuc | 4/4 (100) | 3/4 (75) | 0/4 (0) |
T tumor development, D intrathoracic dissemination by gross appearance, DM distant metastasis. Liver and brain were analyzed as examples of common sites of lung cancer metastasis
