Figure 1. STIM1 in T cells is required to control chronic Mtb infection in mice.

(A and B) Survival curves (A) and lung bacterial burden (B) of Stim1^CD4 and WT control mice infected with 100 CFU of aerosolized Mtb strain H37Rv. Results are representative of 3 independent experiments. (C) H&E stains of lung sections at 114 d.p.i. Pictures are representative of 5 mice per group. Original magnification, ×40. (D) Averaged total numbers of live cells isolated from the lungs of 3 to 5 mice per group and time point. (E) Open alveolar spaces quantified from histological sections in part C of 4–5 mice per group and time point using ImageJ software. Statistical significance was calculated by Student’s t test. *P < 0.05; **P < 0.01; ***P < 0.001.