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. Author manuscript; available in PMC: 2015 Jul 29.
Published in final edited form as: Annu Rev Neurosci. 2006;29:229–257. doi: 10.1146/annurev.neuro.29.051605.112824

Figure 4.

Figure 4

Blood flow changes associated with the presence of tremor or other movement of the upper extremities during 1-min positron emission tomography (PET) scans in patients (n = 8) with subthalamic nucleus deep brain stimulation (STN DBS). These scans were collected with STN DBS off as part of a larger study of stimulation (Hershey et al. 2003). The image represents an averaged change in blood flow comparing paired scans for each patient with both STN stimulators off. During one scan there was no movement detected by videography or direct observation and no excessive activity seen on surface electromyography. During another scan there was movement or tremor. Arrows indicate peak blood flow increase of 5% in sensorimotor cortex. Such changes in motor behavior during PETs to investigate effects of DBS can confound the interpretation of findings. The scans collected during movement were excluded from our analysis of STN DBS effects (Hershey et al. 2003).