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. Author manuscript; available in PMC: 2016 May 5.
Published in final edited form as: Brain Res. 2015 Feb 23;1606:133–141. doi: 10.1016/j.brainres.2015.02.031

Fig. 3.

Fig. 3

Controlled cortical impact (CCI) administered post-fear conditioning (p.c.) does not affect fear expression or extinction. (A) Experimental timeline: sham injury and CCI occurred 24 h after conditioning (Cond). Following a two-week recovery period, all mice underwent extinction training (Ext) and test for extinction memory (Test). (B) Sham controls (n=14) and p.c. CCI (n=14) displayed comparable levels of freezing 30 s immediately prior to the first tone of extinction (Ext; shaded region) and prior to the first tone of test (Test; shaded region). Sham controls and CCI had similar levels of freezing during Cond, Ext, and Test. (C) Total distance traveled in the open field between sham (n=10) and CCI (n=10) was also similar, suggesting that CCI does not affect locomotor activity.