Skip to main content
. Author manuscript; available in PMC: 2015 Jul 29.
Published in final edited form as: J Biol Chem. 2003 Feb 13;278(16):14013–14019. doi: 10.1074/jbc.M209702200

Fig. 1. Role of MAPK signaling in endogenous HIF-1 activity.

Fig. 1

A, schematic representation of MAPK-signaling pathway and the sites for inhibitor action. B, model of the luciferase-reporter system. C and D, effects of genistein on HIF-1 activity. B1 cells were exposed to various doses of genistein, a tyrosine kinase inhibitor, and cultured in normoxia (C) or in a hypoxic work station with 2% O2 (D) for 8 h. E and F, effects of PDx on HIF-1 activity. B1 cells were exposed to various doses of PDx, MAPK inhibitor, under normoxic or hypoxic conditions (2% O2) for 8 h. RLU, relative light units.