Fig. 4. Expression of the PFKFB3 gene in pVHL-deficient cells.
a, total RNA from normoxic VHL deficient (−) renal carcinoma 786-0 cells and their VHL positive (+) controls where analyzed for PFKFB3, Glut-1, and VEGF mRNA expression by RNase protection assays. b, whole cell extracts from VHL (+) and VHL (−) were analyzed by Western blots using anti-HIF-2α and anti-VHL antibodies.