Table 2.

Effect of oral administration of TAF- Cs, and loperamide on castor oil induced diarrhea in mice

Treatment (v.o.)	Dose (mg/kg)	Evacuation Index (EI)
12 % Tween 80 solution	-	15.0 (10.0 - 23.0)
Loperamide	5	0.0 (0.9 - 2.0)***
TAF-Cs	62.5	13.5 (6.0 - 16.0)
TAF-Cs	125	6.0 (4.0 - 8.0)
TAF-Cs	250	1.0 (0.0 - 5.0)**
TAF-Cs	500	1.0 (0.0 - 2.0)**

Data are presented as median (minimum value – maximum value). Kruskal-Wallis test followed by Dunn’s multiple comparison test (** p <0.05, *** p <0.001 compared to the 12% Tween solution group). The TAF-Cs reduced evacuation index (250 and 500 mg/kg) compared to control group (12% Tween 80 solution).