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. 2015 Jul 29;10(7):e0131842. doi: 10.1371/journal.pone.0131842

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Fig 4 — MM2BH cell clones grown on glass coverslips were fixed, permeabilized and immunostained. (A) Deficiency of αv-integrin results in increased cytoplasmic localization of HER2 receptors. Yellow: HER2, using an antibody specific for the HER2 intracellular domain, red: f-actin, blue: nucleus. (B) HER2 co-localizes with lysosomes in αv-integrin knockdown cells. Yellow: HER2, red: lysosome-associated membrane protein2 (LAMP2), blue: nucleus. The images are representative of three independent experiments. Scale bar = 20μm. (C) Flow cytometry analysis of surface HER2 protein expression in live MM2BH clones.