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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Ann Emerg Med. 2015 Feb 18;65(5):532–539. doi: 10.1016/j.annemergmed.2014.12.010

Table 2.

Typical dose selection for oral anticoagulants initiated in the ED for patients without evidence of renal failure (eg, creatinine clearance >60 mL/minute), with instructions to follow up with the primary care provider.2,5,9

Oral Anticoagulant Patient Initiating Dose/Prescription
Warfarin ≥70 kg 5 mg once daily×3–5 days; obtain INR
≤60 kg or age ≥80 y 2.5 mg once daily×3–5 days; obtain INR
Novel oral anticoagulants
Dabigatran ≥70 kg 150 mg twice daily×1–2 wk
≤60 kg or age ≥80 y 110 mg twice daily×1–2 wk
US: 75 mg twice daily×1–2 wk*
Rivaroxaban ≥70 kg 20 mg once daily×1–2 wk
≤60 kg or age ≥80 y 15 mg once daily×1–2 wk
Apixaban ≥70 kg 5.0 mg twice daily×1–2 wk
≤60 kg or age ≥80 y 2.5 mg twice daily×1–2 wk
*

This is the Food and Drug Administration recommended dose, based on modeling studies; however, it has not been prospectively validated. Other countries use 110 mg twice a day as the lower dose.