Table 1. Canonical pathways functionally associated with CR-suppressed expression signature in older-adult hippocampal CA1.
(p<0.01, q<0.05).
| Canonical pathway | p-value | Altered genes / Known related genes | Upregulated by CR (Downregulated in normal aging) | Downregulated by CR (Upregulated in normal aging) |
|---|---|---|---|---|
| Calcium signaling | 7.35E-06 | 22/140 (16%) | Atp2b1, Camk2b, Camkk1, Chrna5, Gria1, Grin2a, Grin2b, Ppp3ca, Ryr3, Trpc4 | Atp2b4, Camk1, Camk2d, Camk4, Chrna4, Chrna6, Chrnb3, Gria4, Itpr3, Mef2c, Slc8a3, Trpc3 |
| Axonal guidance signaling | 4.93E-05 | 38/352 (11%) | Actr2, Actr3, Arpc2, Arpc5, Epha4, Epha6, Epha7, Git1, Gnaq, Gng10, Gng7, Nrp1, Ppp3ca, Prkce, Prkcg, Sema3e, Sema5a, Slit1, Slit3, Wnt2 | Bmp7, Ecel1, Efna5, Epha8, Gnb4, L1cam, Ngef, Pak7, Plcb4, Plxna3, Plxnd1, Rnd1, Sema3a, Sema3f, Sema4a, Unc5d, Wnt10a, Wnt6 |
| Corticotropin releasing hormone signaling | 2.19E-04 | 15/96 (16%) | Arpc5, Elk1, Gnaq, Npr1, Prkce, Prkcg | Adcy8, Camk4, Crh, Crhr1, Fos, Gucy1a3, Itpr3, Mapk11, Mef2c |
| Synaptic long term potentiation | 3.47E-04 | 15/100 (15%) | Camk2b, Gnaq, Gria1, Grin2a, Grin2b, Grm1, Ppp3ca, Prkce, Prkcg | Adcy8, Camk2d, Camk4, Gria4, Itpr3, Plcb4 |
| Creb signaling in neurons | 5.12E-04 | 19/149 (13%) | Camk2b, Elk1, Gnaq, Gng10, Gng7, Gria1, Grin2a, Grin2b, Grm1, Prkce, Prkcg | Adcy8, Camk2d, Camk4, Gnb4, Gria4, Grik3, Itpr3, Plcb4 |
| G-protein coupled receptor signaling | 3.23E-04 | 26/228 (11%) | Drd5, Dusp6, Gnaq, Grm1, Htr1a, Htr4, Mc4r, Prkce, Prkcg, Ptk2b, Rasgrp1, Rgs14 | Adcy8, Adra1b, Adrb3, Camk2d, Camk4, Crhr1, Dusp1, Hrh1, Htr2c, Htr7, Oprk1, Pde4d, Plcb4, Ptgdr |