Table 3. Between group differences based on time for longitudinal, oblique transverse planes of uterine AP measurements or RI and PI measurements of the uterine and superficial arteries (per protocol analysis, N = 49).

Outcomes	Group	Day 3	Week 2	Week 4	Week 6	F-statistic	p-value
		Mean (95% CI)	Mean (95% CI)	Mean (95% CI)	Mean (95% CI)
Uterine AP measurement
Longitudinal	C.striatus	73.25	55.48	41.28	29.26	23.6(1)	<0.001*
	(N = 25)	(69.60, 76.90)	(52.58, 58.39)	(39.28, 43.28)	(26.84, 31.69)
	Placebo	74.92	60.61	50.69	40.55
	(N = 24)	(71.19, 78.65)	(57.65, 63.58)	(48.65, 52.74)	(38.08, 43.03)
Oblique Transverse plane	C.striatus	76.99	58.94	44.32	30.74	10.9(1)	0.002*
	(N = 25)	(73.18, 80.80)	(56.17, 61.71)	(41.82, 46.81)	(28.43, 33.05)
	Placebo	74.21	61.34	52.60	41.25
	(N = 24)	(70.32, 78.10)	(58.51, 64.17)	(50.05, 55.14)	(38.89, 43.61)
Uterine artery RI	C.striatus	0.44	0.58	0.69	0.81	1.4(1)	0.248*
	(N = 25)	(0.40, 0.48)	(0.55, 0.61)	(0.66, 0.71)	(0.78, 0.84)
	Placebo	0.43	0.54	0.67	0.80
	(N = 24)	(0.39, 0.47)	(0.51, 0.58)	(0.64, 0.70)	(0.77, 0.83)
Uterine artery PI	C.striatus	0.91	1.18	1.35	1.78	5.2(1)	0.027*
	(N = 25)	(0.85, 0.96)	(1.11, 1.24)	(1.29, 1.41)	(1.72, 1.83)
	Placebo	0.80	1.39	1.40	1.73
	(N = 24)	(0.74, 0.85)	(1.03, 1.16)	(1.34, 1.45)	(1.68, 1.78)
Superficial skin artery RI	C.striatus	0.42	0.57	0.68	0.80	1.6(1)	0.213*
	(n = 25)	(0.38, 0.46)	(0.54, 0.60)	(0.65, 0.71)	(0.77, 0.83)
	Placebo	0.45	0.54	0.62	0.76
	(N = 24)	(0.41, 0.50)	(0.51, 0.57)	(0.59, 0.66)	(0.73, 0.79)
Superficial skin artery PI	C.striatus	0.90	1.14	1.33	1.76	3.0(1)	0.089*
	(N = 25)	(0.83, 0.96)	(1.09, 1.20)	(1.26, 1.40)	(1.67, 1.85)
	Placebo	0.84	1.10	1.34	1.62
	(N = 24)	(0.77, 0.90)	(1.04, 1.16)	(1.27, 1.41)	(1.53, 1.71)

AP, anterior posterior; RI, resistive index; PI, pulsatility index.

*Repeated measure ANOVA was applied followed by pairwise comparison with Bonferroni confidence interval adjustment. Assumption of normality, homogeneity of variances and compound symmetry were checked and fulfilled.