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. Author manuscript; available in PMC: 2015 Jul 29.
Published in final edited form as: Bioorg Med Chem. 2013 Oct 5;21(23):7309–7329. doi: 10.1016/j.bmc.2013.09.060

Figure 1.

Figure 1

Structures of (-)-cytisine 1, cytisine derivatives 4–7 and the development of the 3,7-diazabicyclo[3.3.1]nonane based compounds 13–55 incorporating a spacer motif, e.g. compounds 30, 31, 36, and 37.