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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: J Clin Endocrinol Metab. 2014 Dec 11;100(3):1018–1027. doi: 10.1210/jc.2014-3096

Table 3.

Relationships between LSBMD Z-Score and Vertebral Fractures

Age Group (proportion of children with fractures) Reference database Odds ratio$ (95% CI*) p-value from Cochran’s Q test AUC# (95% CI*) p-value from Cochran’s Q test NRI+ (95% CI) p-value
0–18 years (29/186) Hologic 12.3 (20) 2.36 (1.58, 3.53) 0.61 0.74 (0.63, 0.85) 0.98 Reference
Hologic Apex 3.1 (15) +Kalkwarf 2013 (21) 2.05 (1.49, 2.82) 0.73 (0.61, 0.84) −0.06 (−0.45, 0.33) 0.75
Zemel 2011 (16) + Kalkwarf 2013 (21) 1.92 (1.44, 2.56) 0.71 (0.60, 0.83) −0.15 (−0.54, 0.25) 0.46
Del Rio 1994 (24) 2.70 (1.70, 4.28) 0.75 (0.63, 0.86) 0.07 (−0.32, 0.47) 0.72
0–5 years (10/86) Hologic 12.3 (20) 11.36 (2.78, 46.40) 0.98 0.95 (0.89, 1.00) 0.61 Reference
Del Rio 1994 (24) 11.66 (2.93, 46.38) 0.92 (0.80, 1.00) −0.67 (−1.31, −0.03) 0.04
3–18 years (26/153) Hologic 12.3 (20) 2.22 (1.47, 3.35) 0.99 0.73 (0.60, 0.85) >0.99 Reference
Hologic Apex 3.1 (15) 2.08 (1.46, 2.97) 0.72 (0.60, 0.84) 0.29 (−0.13, 0.71) 0.18
Del Rio 1994 (24) 2.40 (1.49, 3.86) 0.72 (0.60, 0.85) −0.15 (−0.56, 0.27) 0.49
Kelly 2005 (34) 2.17 (1.49, 3.17) 0.72 (0.60, 0.84) 0.41 (0.00, 0.83) 0.05
Webber 2007 (23) 2.23 (1.47, 3.39) 0.71 (0.58, 0.83) −0.02 (−0.44, 0.40) 0.92
5–18 years§ (19/100) Hologic 12.3 (20) 1.66 (1.07, 2.60) >0.99 0.67 (0.52, 0.82) >0.99 Reference
Hologic Apex 3.1 (15) 1.69 (1.14, 2.52) 0.68 (0.53, 0.83) 0.28 (−0.21, 0.77) 0.27
Zemel 2011 (16) 1.63 (1.10, 2.42) 0.67 (0.52, 0.82) 0.10 (−0.39, 0.59) 0.69
Lunar (USA) 2010 (27) 1.71 (1.08, 2.73) 0.67 (0.52, 0.82) −0.10 (−0.59, 0.38) 0.69
Del Rio 1994 (24) 1.68 (1.04, 2.69) 0.67 (0.51, 0.82) 0.11 (−0.38, 0.61) 0.65
Kelly 2005 (34) 1.68 (1.10, 2.55) 0.68 (0.52, 0.83) 0.13 (−0.36, 0.62) 0.61
Pludowski 2005 (26) 1.89 (1.11, 3.21) 0.68 (0.52, 0.84) 0.24 (−0.25, 0.74) 0.33
van der Sluis 2002 (25) 1.59 (1.01, 2.50) 0.66 (0.52, 0.80) −0.37 (−0.86, 0.11) 0.13
Webber 2007 (23) 1.65 (1.07, 2.55) 0.66 (0.51, 0.81) 0.21 (−0.28, 0.71) 0.40
8–16 years§ (10/51) Hologic 12.3 (20) 2.31 (1.16, 4.59) >0.99 0.76 (0.57, 0.95) >0.99 Reference
Hologic Apex 3.1 (15) 2.52 (1.25, 5.08) 0.81 (0.65, 0.98) 0.67 (0.03, 1.31) 0.04
Zemel 2011 (16) 2.45 (1.22, 4.92) 0.79 (0.62, 0.96) 0.42 (−0.26, 1.10) 0.22
Lunar (BMDCS) 2010 (27) 2.63 (1.27, 5.44) 0.80 (0.63, 0.98) 0.47 (−0.21, 1.14) 0.17
Lunar (USA) 2010 (27) 2.78 (1.25, 6.19) 0.80 (0.62, 0.98) 0.57 (−0.07, 1.21) 0.08
Del Rio 1994 (24) 2.05 (1.05, 3.99) 0.76 (0.55, 0.96) −0.57 (−1.21, 0.07) 0.08
Faulkner 1996 (28) 2.09 (1.14, 3.83) 0.76 (0.55, 0.96) 0.02 (−0.67, 0.72) 0.94
Kalkwarf 2007 (33) 2.41 (1.21, 4.79) 0.79 (0.62, 0.96) 0.42 (−0.26, 1.10) 0.22
Kelly 2005 (34) 2.56 (1.24, 5.31) 0.80 (0.62, 0.97) 0.52 (−0.12, 1.17) 0.11
Pludowski 2005 (26) 2.58 (1.25, 5.34) 0.78 (0.58, 0.98) 0.77 (0.19, 1.35) 0.01
van der Sluis 2002 (25) 2.87 (1.25, 6.56) 0.81 (0.62, 1.00) 0.47 (−0.17, 1.12) 0.15
Webber 2007 (23) 2.09 (1.10, 4.00) 0.76 (0.58, 0.95) −0.07 (−0.76, 0.62) 0.84
9–14 years§ (7/37) Hologic 12.3 (20) 4.27 (1.36, 13.44) 0.97 0.85 (0.66, 1.00) >0.99 Reference
Hologic Apex 3.1 (15) 6.00 (1.46, 24.63) 0.90 (0.73, 1.00) 0.61 (−0.19, 1.41) 0.13
Zemel 2011 (16) 5.36 (1.44, 19.94) 0.88 (0.73, 1.00) 0.90 (0.15, 1.64) 0.02
Lunar (BMDCS) 2010 (27) 6.67 (1.54, 28.91) 0.89 (0.72, 1.00) 0.68 (−0.12, 1.47) 0.09
Lunar (USA) 2010 (27) 11.22 (1.77, 71.28) 0.89 (0.73, 1.00) 0.81 (0.03, 1.59) 0.04
Bachrach 1999 (22) 18.06 (1.82, 178.99) 0.94 (0.86, 1.00) 1.18 (0.57, 1.79) <0.01
Del Rio 1994 (24) 6.44 (1.58, 26.35) 0.89 (0.76, 1.00) 0.41 (−0.40, 1.22) 0.32
Faulkner 1996 (28) 2.95 (1.13, 7.69) 0.82 (0.60, 1.00) −0.98(−1.60, −0.36) <0.01
Fonseca 2001 (32) 4.05 (1.38, 11.90) 0.87 (0.73, 1.00) −0.21 (−1.03, 0.61) 0.61
Kalkwarf 2007 (33) 5.29 (1.42, 19.68) 0.87 (0.72, 1.00) 0.61 (−0.19, 1.41) 0.13
Kelly 2005 (34) 7.14 (1.57, 32.44) 0.89 (0.74, 1.00) 0.32 (−0.47, 1.12) 0.43
Pludowski 2005 (26) 5.15 (1.50, 17.68) 0.87 (0.70, 1.00) 0.56 (−0.20, 1.32) 0.15
van der Sluis 2002 (25) 19.02 (1.85, 195.78) 0.91 (0.79, 1.00) 1.67 (1.40, 1.93) <0.01
Webber 2007 (23) 4.75 (1.30, 17.43) 0.85 (0.68, 1.00) −0.01 (−0.82, 0.81) 0.98

Note:

*

CI = confidence interval

#

AUC = area under the receiver operating characteristic curve

+

NRI = net reclassification improvement

$

Odds ratio = odds per standard deviation decrease in lumbar spine bone mineral density Z-score

§

Statistical analyses are based on the height Z-score-adjusted LSBMD Z-scores for this age group.