Table 1. Reduction in viral load of infected duck embryonic fibroblast (DEF) cells following treatment with Ribavirin.
PaBV-4 positive cell foci | Area of infected cells (%) | ||||
---|---|---|---|---|---|
Virus (ffu) | Ribavirin (μg/mL) | Median | (25th– 75th percentile) | Median | (25th– 75th percentile) |
64 | 0 | 36 | 35–37 | 47.7 | 47.2–48.2 |
0.25 | 40 | 33–46 | 49.5 | 46.7–52.3 | |
2.5 | 73 | 72–73 | 30.6 | 29.0–32.2 | |
25.0 | 1 | 0.5–1.5 | 0.4 | 0.4–0.5 | |
7 | 0 | 50 | 48–51 | 9.1 | 8.5–9.8 |
0.25 | 73 | 72–73 | 12.5 | 12.0–13.0 | |
2.5 | 19 | 18–20 | 4.3 | 4.1–4.5 | |
25.0 | 2 | 2–2 | 0.5 | 0.4–0.5 | |
1 | 0 | 7 | 6–7 | 1.6 | 1.5–1.6 |
0.25 | 7 | 6–9 | 1.3 | 1.0–1.6 | |
2.5 | 4 | 3–4 | 0.9 | 0.9–0.9 | |
25.0 | 1 | 0–1 | 0.6 | 0.6–0.6 | |
No virus (negative control) | 0 | 0 | 0 | 0.2 | 0.2–0.3 |
0.25 | 1 | 0.5–1.5 | 0.2 | 0.2–0.2 | |
2.5 | 0 | 0 | 0.4 | 0.4–0.4 | |
25.0 | 1 | 0.5–1.5 | 0.7 | 0.6–0.8 |
Cells infected with 0.05 and 0.005 ffu had PaBV-4 positive cell foci and percent area of infected cells similar to No virus (negative control).