Fig 8. Effect of the miRCURY LNA mir17-5p inhibitor or scramble control on stress-induced visceral hyperalgesia.
A) EMG response to graded CRD at baseline and 24 hours following the 10th stress session showed overall increase of the EMG response to CRD with significant increased at 40 mmHg consistent with stress-induced visceral hyperalgesia n = 8 *P<0.05 two-way ANOVA followed by Bonferroni post test. B) Stressed rats treated with the LNAmir17-5p inhibitor exhibit increased EMG response to CRD at day 11 compared with baseline indicating visceral hyperalgesia n = 6, *P<0.05 two-way ANOVA followed by Bonferroni post test. C) The mean change from baseline was significantly higher in stressed rats treated with the LNAmir17-5p inhibitor (n = 6) compared with stressed rats treated with the control scramble (n = 8) indicating an exacerbation of visceral sensitivity *P<0.05 two-way ANOVA followed by Bonferroni post test.