Fig 2. Liver injury and inflammation were attenuated in NOX1KO and NOX4KO mice after CCl₄ injury.

Livers were obtained from WT, NOX1KO, and NOX4KO mice by 12 intragastric administrations with CCl₄ for 6 weeks, twice a week. (A) H&E staining of liver sections and F4/80 immunohistochemistry staining with (C) its quantification. Original magnification X10. (C) Hepatic mRNAs of inflammatory genes was measured in WT, NOX1KO and NOX4KO mice after CCl₄ injury by way of quantitative real-time PCR. HPRT was used as an internal control. The data are shown as fold mRNA induction compared with control mice. *P <0.05, **P < 0.01.