Table 3. Inhibitory effect of different compounds on enzymatic activity.

IC50 (μM)
Inhibitor	AKR1B15	AKR1B10	AKR1B1
Tolrestat	> 100	0.006	0.01 a
Sorbinil	> 100	9.6 b	0.55 b
JF0064	0.034 ± 0.005	1.0 d	0.3 d
Epalrestat	> 50	0.33 c	0.021 c
Oleanolic acid	> 100	0.09 b	124 b
Sulindac	>100	0.35 c	0.21 c
Lithocholic acid	16.3 ± 7.6	0.12 d	7.2 d

The enzymatic activity assay with inhibitors was performed by using d,l-glyceraldehyde as a substrate. JF0064: 2,2’,3,3’,5,5’,6,6’-octafluoro-4,4’-biphenyldiol

^aData from [70].

^bData from [52].

^cData from [71].

^dData from [66]