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. 2015 Jul 29;11(7):e1005065. doi: 10.1371/journal.ppat.1005065

Fig 2. IL-27 signaling suppresses systemic inflammatory responses in mice infected with T. congolense.

Fig 2

(A) Plasma levels of IFN-γ, IL-12p40, and TNF-α in IL-27R-/- (WSX-1-/-) and wild-type mice (n = 4) on day 7 and 10 after infection with T. congolense. (B) Secretions of IFN-γ, IL-12p40 and TNF-α in the supernatant fluids of cultured spleen cells purified from IL-27R-/- and wild-type mice (n = 4) on day 7 and 10 following infection with T. congolense. (C) The frequency (left and upper right) and the absolute number (lower right) of splenic IFN-γ-producing CD4+ T cells derived from IL-27R-/- and wild-type mice (n = 3) on day 0, 7 and 10 after infection following 12 h in vitro restimulation with Cell Stimulation Cocktail (containing PMA, ionomycin, and protein transport inhibitors). Data are presented as the mean ± SEM. The results presented are representative of 2–3 separate experiments.