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. 2015 Jul 29;11(7):e1005065. doi: 10.1371/journal.ppat.1005065

Fig 6. Depletion of CD4+, but not CD8+, T cells significantly reduces the production of inflammatory cytokines and the serum activities of ALT, and enhances the survival of IL-27R-/- (WSX-1-/-) mice infected with T. congolense.

Fig 6

IL-27R-/- mice were infected with T. congolense, and treated with 0.5 mg rat anti-mouse CD4 mAb, rat anti-mouse CD8 mAb, or rat IgG on day 0, 2, 4, and 6 after infection, respectively. (A) Parasitemia and survival of the IL-27R-/- mice (n = 4–5) infected with T. congolense. (B) Serum ALT activities were assessed in IL-27R-/- mice (n = 4) on day 7 after infection with T. congolense. (C) Plasma levels of IFN-γ, IL-12p40, and TNF-α of IL-27R-/- mice (n = 4) on day 7 after infection with T. congolense. Data are presented as the mean ± SEM. The results presented are representative of 2 separate experiments.