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. 2015 Jul 29;11(7):e1005065. doi: 10.1371/journal.ppat.1005065

Fig 7. Neutralization of IFN-γ significantly reduces the production of inflammatory cytokines and the serum activities of ALT, and prevents the early mortality of IL-27R-/- (WSX-1-/-) mice infected with T. congolense.

Fig 7

IL-27R-/- mice were infected with T. congolense, and treated with 0.4 mg rat anti-mouse IFN-γ mAb or rat IgG on day 0, 2, 4, 6, 8, 10, 12, and 14 after infection, respectively. (A) Parasitemia and survival of infected IL-27R-/- mice (n = 5). (B) Serum ALT activities were assessed in IL-27R-/- mice (n = 4) on day 7 after infection. (C) Plasma levels of IFN-γ, IL-12p40, and TNF-α of IL-27R-/- mice (n = 4) on day 7 after infection. Data are presented as the mean ± SEM. The results presented are representative of 2 separate experiments.