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. 2015 Jul 29;11(7):e1005065. doi: 10.1371/journal.ppat.1005065

Fig 8. IL-27 signaling plays a crucial role in dampening Th1 mediated immune responses, allowing prolonged survival of mice infected with T. brucei.

Fig 8

(A) mRNA expression levels of IL-27p28, EBI3 and WSX-1 in the liver of wild-type mice infected with T. brucei on day 6 and 9 versus day 0 (uninfected). (B) Parasitemia and survival of IL-27R-/- (WSX-1-/-) and wild-type mice (n = 6–7) infected with T. brucei. (C) Production of IFN-γ detected on day 6 in the plasma and supernatant fluids of cultured spleen cells and serum activities of ALT examined on day 6 and 9 in IL-27R-/- and wild-type mice after infection with T. brucei. (D) Survival of IL-27R-/- mice (n = 5–6) infected with T. brucei, following administration of 0.5 mg rat anti-mouse CD4 mAb, rat anti-mouse CD8 mAb, or rat IgG on day 0, 2, 4, and 6 after infection, respectively. Data are presented as the mean ± SEM. The results presented are representative of 2–3 separate experiments.